The United States holds most of the organizations mapped in this directory: exchanges, custodians, asset managers, miners and analytics firms. That concentration reflects where capital and operating companies are, not where on-chain activity lives, which is global by definition. The regulatory environment is fragmented, with authority split across several federal agencies and individual states.
What to compare: Look at the location type on each entry: a corporate headquarters, a mining facility and a registered office say very different things about an organization's real presence in the country.
56 entries
San Francisco · Alchemy HQ
A major Web3 developer platform for RPC, APIs, account abstraction, and app tooling.
San Francisco · Anchorage Digital
Digital asset platform providing custody and financial services for institutions.
Palo Alto · Aptos Labs
A Move-based L1 backed by a large foundation, payments work, and consumer app focus.
New York · Offchain Labs
A major Ethereum L2 ecosystem with deep DeFi liquidity and the Arbitrum Orbit stack.
New York · Ava Labs
A network focused on high-speed apps, custom L1s, institutions, gaming, and tokenization.
San Francisco · Coinbase / Base
An OP Stack Layer 2 designed to bring Coinbase users and builders on-chain.
Washington · Bitcoin Policy Institute
Policy research organization focused on Bitcoin regulation, energy, financial inclusion, and national security.
Palo Alto · BitGo
Institutional digital asset custody, wallets, staking, trading, and settlement services.
San Francisco · Bitwave
Enterprise back-office platform for digital asset accounting, tax tracking, invoicing, and bookkeeping.
New York · BlackRock
Major asset manager active in spot crypto ETFs and tokenized fund infrastructure.
San Francisco · Block
Financial technology company behind Square, Cash App, Bitkey, and Bitcoin mining hardware initiatives.
Los Angeles · Blockdaemon
Node, staking, and blockchain infrastructure provider for institutions.
San Francisco · Celo Foundation
Foundation supporting Celo, a mobile-first ecosystem focused on stablecoin payments and real-world usage.
New York · CertiK
Blockchain security company providing smart contract audits, monitoring, and risk tooling.
New York · Chainalysis
Blockchain analytics company serving compliance, investigations, risk and government workflows. Co-founded in 2014, it states it serves government agencies, exchanges, financial institutions and cybersecurity companies across more than 70 countries. Its work turning transactions into attributed entity data is what makes chain activity legible to law enforcement, which is also why it draws privacy criticism.
San Francisco · Chainlink Labs
The dominant oracle network, expanding into cross-chain messaging, market data, and RWA infrastructure.
Boston · Circle
Issuer of USDC and provider of stablecoin settlement, treasury, and payment infrastructure. USDC is issued through regulated Circle affiliates, and Circle publishes weekly reserve holdings alongside a monthly third-party attestation.
Henderson · CleanSpark
US Bitcoin miner focused on owned mining sites, energy strategy, and operational scale.
Boston · Coin Metrics
Provider of crypto financial intelligence, network data, and market data products.
San Francisco · Coinbase
A major US crypto exchange spanning retail, custody, prime brokerage, staking, and Base.
Austin · Core Scientific
Large mining and data-center operator connecting Bitcoin hashrate with broader compute demand.
Seattle · Eigen Labs
Ethereum restaking infrastructure for shared security, AVSs, and new crypto-economic services.
Omaha · Exodus
Multi-asset self-custody wallet across desktop, mobile, and browser.
New York · Fireblocks
Institutional custody, wallet, settlement, tokenization, and payment infrastructure.
New York · Galaxy
Diversified digital asset firm spanning trading, asset management, mining, advisory, and research.
New York · Gemini
Digital asset platform with exchange, custody, and institutional services.
Stamford · Grayscale
Crypto asset manager known for trusts, ETFs, and institutional digital asset products.
Miami · Hut 8
Bitcoin mining and energy infrastructure company with North American operations.
San Francisco · Kraken
Long-running exchange with retail, pro trading, staking, OTC and institutional services, operating since 2011 under the entity Payward, Inc. Kraken states that its regulatory status differs per jurisdiction and that geographic restrictions apply, so which products are available depends on where a user is.
New York · Consensys / Linea
Ethereum-equivalent zkEVM Layer 2 developed by Consensys for low-cost on-chain applications.
Fort Lauderdale · MARA Holdings
Large public Bitcoin mining company with industrial-scale operations and treasury exposure.
Purchase · Mastercard crypto programs
Global payments network active in digital asset cards, blockchain partnerships, and crypto payment infrastructure.
New York · Consensys / MetaMask
The most recognizable Ethereum and EVM self-custody wallet for browsers and mobile.
New York · Monad Labs
Core team building Monad, a high-performance EVM-compatible Layer 1 with parallel execution.
New York · Ondo Finance
RWA protocol focused on tokenized US Treasuries, institutional yield, and on-chain finance.
San Francisco · OpenZeppelin
Security standard-setter behind widely used smart contract libraries, audits, and operations tooling.
New York · Paxos
Regulated blockchain infrastructure for stablecoins, tokenization, brokerage, and settlement.
San Francisco · Phantom
A leading consumer wallet that started on Solana and expanded into Ethereum, Bitcoin, and multichain use.
San Francisco · Polychain Capital
Investment firm backing blockchain protocols, token networks, and crypto infrastructure companies.
San Francisco · Portal to Bitcoin
Bitcoin-native infrastructure focused on private, non-custodial trading without giving up coin control.
Miami · QuickNode HQ
Multi-chain infrastructure for RPC endpoints, data streams, functions, and developer APIs.
New York · Rain
Stablecoin payments infrastructure for card programs, cross-border payments, and embedded wallet flows.
Castle Rock · Riot Platforms
Public Bitcoin mining company operating large-scale mining and power infrastructure.
San Francisco · Ripple
Enterprise blockchain company focused on cross-border payments, custody, tokenization, and XRPL.
Miami · Securitize
Regulated platform for issuing, managing, and trading tokenized securities and funds.
San Francisco · Solana Labs
A fast monolithic chain with strong activity in DeFi, payments, consumer apps, and DePIN.
San Francisco · Spiral
Block-backed initiative funding and building open-source Bitcoin projects, Lightning tools, and developer resources.
San Francisco · Stellar Development Foundation
Foundation supporting Stellar infrastructure for payments, remittances, tokenization, and financial access.
Tysons Corner · Strategy Bitcoin treasury
Public company known for a large corporate Bitcoin treasury and capital markets strategy.
Palo Alto · Mysten Labs
A high-performance Move chain with object-centric design and strong consumer app ambitions.
San Francisco · The Graph ecosystem
Decentralized indexing protocol powering subgraphs and query layers for blockchain applications.
San Francisco · TRM Labs
Blockchain intelligence platform for financial crime compliance, investigations, and risk monitoring.
New York · Turnkey
Wallet infrastructure company for secure embedded wallets, key management, and crypto application onboarding.
New York · Uniswap Labs
Creator of the leading AMM protocol and a core liquidity layer across Ethereum and EVM chains.
Hoboken · ZBD
Payments company using Bitcoin and Lightning for real-money rewards and transactions inside games.
San Francisco · ZetaChain ecosystem
Interoperability network for building applications that connect assets and users across chains.